The Brown Algae: Sargassum binderi Sonder Shows a Potential Nephroprotective Activity in In-Vivo Experimental Model

About Course

This course, “The Brown Algae: Sargassum binderi Sonder Shows a Potential Nephroprotective Activity in In-Vivo Experimental Model,” provides an in-depth exploration of the therapeutic potential of brown algae, focusing on its role in combating nephrotoxicity and oxidative stress. Learners will delve into the experimental methodologies used to extract bioactive compounds from Sargassum binderi, including ethanol, water, and hexane extraction techniques. The course examines the in-vivo experimental model employed to assess the nephroprotective effects, highlighting the biochemical markers such as creatinine, urea, and oxidative stress indicators like malondialdehyde (MDA) and reduced glutathione (GSH). Through detailed analysis of GC-MS profiling, learners will gain insights into the therapeutic compounds identified in Sargassum binderi and their implications for kidney health. Additionally, the course discusses the results, comparing the efficacy of different extracts, and concludes with practical applications in pharmaceuticals and nutraceuticals. With a focus on natural solutions to kidney-related disorders, this course equips learners with the knowledge and skills to explore marine-based resources for advancing healthcare solutions.

Abstract:

This study investigates the nephroprotective potential of the brown seaweed Sargassum binderi through in-vivo experiments, focusing on its ability to counteract kidney damage caused by cisplatin, a commonly used chemotherapeutic agent. The research evaluates ethanolic, water, and n-hexane extracts of Sargassum binderi for their antioxidative properties and impact on key biochemical markers like creatinine, urea, blood urea nitrogen (BUN), malondialdehyde (MDA), and reduced glutathione (GSH). GC-MS analysis of the n-hexane extract revealed bioactive compounds responsible for its therapeutic effects. The study provides valuable insights into the potential applications of Sargassum binderi in developing natural remedies for oxidative stress and nephrotoxicity.

DOI Link:

https://doi.org/10.1016/j.pharma.2024.06.001.

How brown algae, specifically Sargassum binderi, exhibits nephroprotective properties.
The significance of oxidative stress and its role in kidney damage.
Experimental techniques for extracting bioactive compounds from marine resources.
The use of in-vivo models to study the effects of natural remedies on nephrotoxicity.
Key biochemical markers such as creatinine, urea, BUN, MDA, and GSH, and their implications in nephroprotective research.
GC-MS analysis and its application in identifying therapeutic compounds.
Practical applications of Sargassum binderi in developing pharmaceuticals and nutraceuticals.
How natural compounds can contribute to innovative solutions for kidney-related disorders.

Course Content

Module 1: Introduction to Sargassum binderi and Nephrotoxicity
Overview of brown algae and their medicinal potential. Introduction to nephrotoxicity and its clinical significance. Role of Sargassum binderi in combating kidney-related issues.

Module 2: Study Objectives and Research Significance
Understanding the research aims and the importance of nephroprotective studies. Significance of investigating natural solutions for oxidative stress and kidney damage.

Module 3: Experimental Design and Methodology
Collection and preparation of Sargassum binderi samples. Extraction techniques (Ethanol, Water, and Hexane). Overview of the in-vivo experimental model used in the study. Dosage and treatment regimens for nephrotoxicity induction and prevention.

Module 4: Biochemical and Antioxidant Analysis
Explanation of biomarkers used to assess nephroprotective effects. Measurement of creatinine, urea, and blood urea nitrogen (BUN). Analysis of oxidative stress markers such as reduced glutathione (GSH) and malondialdehyde (MDA).

Module 5: GC-MS Profiling and Compound Analysis
Introduction to GC-MS technology for compound identification. Key compounds identified in the hexane extract of Sargassum binderi. Therapeutic significance of these compounds in antioxidant and nephroprotective activities.

Module 6: Results and Discussion
Nephroprotective effects of Sargassum binderi extracts on kidney biomarkers. Hepatoprotective and antioxidant properties demonstrated by the study. Comparison of the efficacy of ethanol and water extracts.

Module 7: Applications and Future Implications
Practical applications of Sargassum binderi in pharmaceuticals and nutraceuticals. Potential for developing natural therapies for nephrotoxicity and other oxidative stress-related conditions. Exploration of future research directions.

Module 8: Conclusion and Course Summary
Key takeaways from the study. Summary of the nephroprotective activity of Sargassum binderi. Importance of research in natural solutions for kidney health.

Student Ratings & Reviews

No Review Yet

The Brown Algae: Sargassum binderi Sonder Shows a Potential Nephroprotective Activity in In-Vivo Experimental Model

About Course

Abstract:

DOI Link:

What Will You Learn?

Course Content

Module 1: Introduction to Sargassum binderi and Nephrotoxicity
Overview of brown algae and their medicinal potential. Introduction to nephrotoxicity and its clinical significance. Role of Sargassum binderi in combating kidney-related issues.

Module 2: Study Objectives and Research Significance
Understanding the research aims and the importance of nephroprotective studies. Significance of investigating natural solutions for oxidative stress and kidney damage.

Module 3: Experimental Design and Methodology
Collection and preparation of Sargassum binderi samples. Extraction techniques (Ethanol, Water, and Hexane). Overview of the in-vivo experimental model used in the study. Dosage and treatment regimens for nephrotoxicity induction and prevention.

Module 4: Biochemical and Antioxidant Analysis
Explanation of biomarkers used to assess nephroprotective effects. Measurement of creatinine, urea, and blood urea nitrogen (BUN). Analysis of oxidative stress markers such as reduced glutathione (GSH) and malondialdehyde (MDA).

Module 5: GC-MS Profiling and Compound Analysis
Introduction to GC-MS technology for compound identification. Key compounds identified in the hexane extract of Sargassum binderi. Therapeutic significance of these compounds in antioxidant and nephroprotective activities.

Module 6: Results and Discussion
Nephroprotective effects of Sargassum binderi extracts on kidney biomarkers. Hepatoprotective and antioxidant properties demonstrated by the study. Comparison of the efficacy of ethanol and water extracts.

Module 7: Applications and Future Implications
Practical applications of Sargassum binderi in pharmaceuticals and nutraceuticals. Potential for developing natural therapies for nephrotoxicity and other oxidative stress-related conditions. Exploration of future research directions.

Module 8: Conclusion and Course Summary
Key takeaways from the study. Summary of the nephroprotective activity of Sargassum binderi. Importance of research in natural solutions for kidney health.

Support

About Course

Abstract:

DOI Link:

What Will You Learn?

Course Content

Module 1: Introduction to Sargassum binderi and Nephrotoxicity Overview of brown algae and their medicinal potential. Introduction to nephrotoxicity and its clinical significance. Role of Sargassum binderi in combating kidney-related issues.

Module 2: Study Objectives and Research Significance Understanding the research aims and the importance of nephroprotective studies. Significance of investigating natural solutions for oxidative stress and kidney damage.

Module 3: Experimental Design and Methodology Collection and preparation of Sargassum binderi samples. Extraction techniques (Ethanol, Water, and Hexane). Overview of the in-vivo experimental model used in the study. Dosage and treatment regimens for nephrotoxicity induction and prevention.

Module 4: Biochemical and Antioxidant Analysis Explanation of biomarkers used to assess nephroprotective effects. Measurement of creatinine, urea, and blood urea nitrogen (BUN). Analysis of oxidative stress markers such as reduced glutathione (GSH) and malondialdehyde (MDA).

Module 5: GC-MS Profiling and Compound Analysis Introduction to GC-MS technology for compound identification. Key compounds identified in the hexane extract of Sargassum binderi. Therapeutic significance of these compounds in antioxidant and nephroprotective activities.

Module 6: Results and Discussion Nephroprotective effects of Sargassum binderi extracts on kidney biomarkers. Hepatoprotective and antioxidant properties demonstrated by the study. Comparison of the efficacy of ethanol and water extracts.

Module 7: Applications and Future Implications Practical applications of Sargassum binderi in pharmaceuticals and nutraceuticals. Potential for developing natural therapies for nephrotoxicity and other oxidative stress-related conditions. Exploration of future research directions.

Module 8: Conclusion and Course Summary Key takeaways from the study. Summary of the nephroprotective activity of Sargassum binderi. Importance of research in natural solutions for kidney health.

Student Ratings & Reviews

Support

Module 1: Introduction to Sargassum binderi and Nephrotoxicity
Overview of brown algae and their medicinal potential. Introduction to nephrotoxicity and its clinical significance. Role of Sargassum binderi in combating kidney-related issues.

Module 2: Study Objectives and Research Significance
Understanding the research aims and the importance of nephroprotective studies. Significance of investigating natural solutions for oxidative stress and kidney damage.

Module 3: Experimental Design and Methodology
Collection and preparation of Sargassum binderi samples. Extraction techniques (Ethanol, Water, and Hexane). Overview of the in-vivo experimental model used in the study. Dosage and treatment regimens for nephrotoxicity induction and prevention.

Module 4: Biochemical and Antioxidant Analysis
Explanation of biomarkers used to assess nephroprotective effects. Measurement of creatinine, urea, and blood urea nitrogen (BUN). Analysis of oxidative stress markers such as reduced glutathione (GSH) and malondialdehyde (MDA).

Module 5: GC-MS Profiling and Compound Analysis
Introduction to GC-MS technology for compound identification. Key compounds identified in the hexane extract of Sargassum binderi. Therapeutic significance of these compounds in antioxidant and nephroprotective activities.

Module 6: Results and Discussion
Nephroprotective effects of Sargassum binderi extracts on kidney biomarkers. Hepatoprotective and antioxidant properties demonstrated by the study. Comparison of the efficacy of ethanol and water extracts.

Module 7: Applications and Future Implications
Practical applications of Sargassum binderi in pharmaceuticals and nutraceuticals. Potential for developing natural therapies for nephrotoxicity and other oxidative stress-related conditions. Exploration of future research directions.

Module 8: Conclusion and Course Summary
Key takeaways from the study. Summary of the nephroprotective activity of Sargassum binderi. Importance of research in natural solutions for kidney health.